Are there food or drug interactions associated with leucovorin?

Question: Are there food or drug interactions associated with leucovorin?

Answer: There are no known food interactions, but there are some drug interactions. Leucovorin can decrease the effectiveness of anti-seizure medicines such as phenobarbital, phenytoin, and primidone. It may also decrease the effectiveness of two antibiotics: Trimethoprim (Bactrim) and Cotrimoxozole (Septra).

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• How is leucovorin administered?
  
  
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• Exactly how does leucovorin work?
  
  
• Are there any food or drug interactions associated with leucovorin?
  
  
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• I'd like to read the Leucovorin product insert.

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<sub>Sources:
1. Bedford Laboratories. Leucovorin product insert.
2. Center for Drug Evaluation and Research. Oncology Tools - Leucovorin Product Label.
3. Cleveland Clinic. What You Need to Know About Leucovorin.
4. Drug Digest. Leucovorin Insert.
5. Hamilton Regional Cancer Centre. Medication Information Sheet: Leucovorin Injection.
6. HealthTouch Online. Leucovorin Injection.
7. Medline Plus. Leucovorin (Systemic).
8. Rx Med. Leucovorin Calcium Injection.</sub>