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Genes

Genetic factors can increase a person's risk of developing colorectal cancer. Here, you can learn about the genes that influence the development of colon and rectum cancer.
Overview: Genetics and Colorectal Cancer Risk
About 75% of colorectal cancer cases are sporadic; they occur in people who have no (or very little) family history of the disease. However, the other 25% of cases are attributed to two types of colorectal cancers: familial and hereditary.
Smoking Increases Risk for Carriers of HNPCC Gene
A study published in the December 13th issue of the Archives of Internal Medicine studied carriers of two HNPCC mutations to determine what lifestyle factors might increase their risk of developing colorectal cancer.
MYH Gene Linked to Colon Cancer
A recent study found that mutations in the MYH gene may be responsible for about 1% of all colorectal cancers in North America.
HNPCC Settles in America
Scientists have combined genetic testing with genealogy to identify a cancer-causing genetic mutation brought to the U.S. by a German immigrant. Their findings are published in the February 11th issue of the Journal of the American Medical Association.
BRCA Mutations May Not Increase Colon Cancer Risk
Currently, national guidelines recommend that carriers of BRCA 1 and BRCA 2 mutations should be informed that they may be at increased risk for developing colorectal cancer. However, recent studies indicate otherwise.
New Colon Cancer Gene Discovered
Researchers have found a gene that is inactivated in 60% of colon cancers. They hope to use this information to screen for the disease.
Insight into the Origin of Colon Cancer
Researchers have known for quite some time that an APC mutation is associated with the development of colon cancer. Now, scientists think they’ve discovered how a mutation in this gene causes the disease.
Smoking Causes Genetic Damage Linked to Colon Cancer
A report published in the November 15th issue of the Journal of the National Cancer Institute found that smoking cigarettes may cause colon cancer by damaging genes.
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